Purpose: Necrotizing enterocolitis(NEC) remains a major cause of morbidity and death in neonates. Evidence suggests that an imbalance between activated proinflammatory response with inadequate antiinflammatory protection results in NEC. Ozone has been proposed as an antioxidant enzyme activator, immunomodulator, and cellular metabolic activator. Therefore, this study was designed to investigate whether medical ozone therapy is effective onneonatal rat model of NEC.
Results: The mortality rate and the waight loss were significantly higher in NEC group than control and treatment groups. Oxidative stress markers significantly increased and antioxidant enzyme activities were significantly decreased in NEC group. All these biohemical changes were ameliorated in NEC group and reduced in treatment group. In addtion, histopathologic injury score of NEC group was significantly higher than NEC + ozone group.